Divergent Syntheses of Resorcylic Acid Lactones: L??783277, LL??Z1640??2, and Hypothemycin

…, G Valot, S Barluenga, N Winssinger

Index: Dakas, Pierre-Yves; Jogireddy, Rajamalleswaramma; Valot, Gaelle; Barluenga, Sofia; Winssinger, Nicolas Chemistry - A European Journal, 2009 , vol. 15, # 43 p. 11490 - 11497

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Citation Number: 41

Abstract

Abstract The resorcylic acid lactones (RAL) are endowed with diverse biological activity ranging from transcription factor modulators (zearalenone and zearalenol) to HSP90 inhibitors (radicicol and pochonin D) and reversible (aigialomycin D) as well as irreversible kinase inhibitors (hypothemycin and other RAL containing a cis-enone). Our interest in broadening the diversity of this family beyond naturally occurring diversity has led us to ...