The preparation of some 3??hydroxy??4??pyridones substituted on the nitrogen atom

RJC Kleipool, JP Wibaut

Index: Kleipool; Wibaut Recueil des Travaux Chimiques des Pays-Bas, 1950 , vol. 69, p. 1041,1046

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Citation Number: 4

Abstract

(From the Laboratory for Organic Chemistry of the Municipal University of Amsterdam). ... N-Methyl-3-hydroxy-4-pyridone-6-carboxylic acid is produced by the action of methylamine on meconic acid and, by splitting off carbon dioxide, N-methyl-3-hydroxy-4-pyridone is obtained. Similar reactions occur with ethylamine and isopropylamine. By the action of these amines on 3-hydroxy-y-pyrone the corresponding N-alkyl-3-hydroxy-4-pyridones are ...