Molecular Docking Studies of (1E, 3E, 5E)-1, 6-Bis (substituted phenyl) hexa-1, 3, 5-triene and 1, 4-Bis (substituted trans-styryl) benzene Analogs as Novel Tyrosinase …

…, HJ Lee, D Park, HO Jeong, JY Park, YJ Park…

Index: Ha, Young Mi; Lee, Hye Jin; Park, Daeui; Jeong, Hyoung Oh; Park, Ji Young; Park, Yun Jung; Lee, Kyung Jin; Lee, Ji Yeon; Moon, Hyung Ryong; Chung, Hae Young Biological and Pharmaceutical Bulletin, 2013 , vol. 36, # 1 p. 55 - 65

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Citation Number: 2

Abstract

We simulated the docking of the tertiary structure of mushroom tyrosinase with our compounds. From the structure-tyrosinase inhibitory activity relationship, it is notable that compounds 4, 8 and 11 showed similar or better activity rates than kojic acid which was used as a positive control. Compounds 17, 21, and 23 among benzene analogs that possess the same substituent showed significantly lower tyrosinase inhibitory effects. ...