(o??Hydroxyphenyl) methylphosphonic acids: Synthesis and potentiometric determinations of their pKa Values

…, J Meullemeestre, MJ Schwing, F Vierling

Index: Boehmer, Volker; Vogt, Walter; Chafaa, Salah; Meullemeestre, Jean; Schwing, Marie-Jose; Vierling, Francois Helvetica Chimica Acta, 1993 , vol. 76, # 1 p. 139 - 149

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Citation Number: 26

Abstract

Abstract (o-Hydroxyphenyl) methylphosphonic acids are readily obtained from o- (bromomethyl)-or o-(hydroxymethyl) phenols and trialkyl phosphites. Subsequent hydrolysis leads to the corresponding phosphonic acids. For a series of such compounds, the pK a values have been determined by potentiometry. Their dependence on additional substituents in the aromatic ring is discussed in terms of electronic and steric effects.