Tetrahedron Letters

Novel and efficient synthesis of 4-sulfonyl-2-pyridones

ML Minich, ID Watson, KJ Filipski, JA Pfefferkorn

Index: Minich, Martha L.; Watson, Isa D.; Filipski, Kevin J.; Pfefferkorn, Jeffrey A. Tetrahedron Letters, 2009 , vol. 50, # 18 p. 2094 - 2096

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Citation Number: 3

Abstract

Heterocyclic 4-sulfonyl-2-pyridones represent useful scaffolds for drug discovery, and are also versatile synthetic building blocks. Herein, we describe a novel and efficient synthesis of this heterocyclic ring system utilizing an acid-mediated cyclo-condensation reaction. This synthetic method affords convenient access to structurally diverse N-substituted 4-sulfonyl-2- pyridones in moderate to good yields.