Semi-synthesis of A. 23187 (calcimycin) analogs with 5-n-amino substituents. Their complexation of calcium and magnesium
F Samih, M Prudhomme, G Dauphin, G Jeminet
Index: Samih, Fouzia; Prudhomme, Michelle; Dauphin, Gerard; Jeminet, Georges Tetrahedron, 1990 , vol. 46, # 15 p. 5177 - 5186
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Citation Number: 5
Abstract
The semi-synthesis of A. 23187 (calcimycin) analogs 14̃ bearing the respective substituents: 5-NH2, 5-NHCH3, 5-N (CH3) 2, 5-NHCOCH3 was carried out. The complexing properties of 14̃ for calcium and magnesium were determined by two-phase experiments (water/toluene- butanol 70: 30 W/W) and found to be much weaker than these of A. 23187 or X. 14885A. There was a discrepancy with theoretical predictions made from model ...
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[Tetrahedron, , vol. 46, # 15 p. 5177 - 5186]