Journal of heterocyclic chemistry

Furopyridines. VII. Preparation and hydrolysis of 2??cyano and 3??cyano derivatives of furo [3, 2??b]??, furo [2, 3??c]??and furo [3, 2??c] pyridine

H Morita, S Shiotani

Index: Morita, Hiroyuki; Shiotani, Shunsaku Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 373 - 376

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Citation Number: 11

Abstract

Abstract This paper describes the preparation and hydrolysis of 2-cyano and 3-cyano derivatives of furo [3, 2-b]-, furo [2, 3-c]-and furo [3, 2-c] pyridine. Treatment of furopyridines 1a, 1b and 1c with n-butyllithium in hexane-tetrahydrofuran at-70 and subsequent addition of N, N-dimethylformamide yielded 2-formyl derivatives 2a, 2b and 2c. Dehydration of the oximes 4a, 4b and 4c of 2a, 2b and 2c gave 2-cyano compounds 5a, 5b and 5c, which ...

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