Aglycone exploration of C-arylglucoside inhibitors of renal sodium-dependent glucose transporter SGLT2

…, M Patel, RN Girotra, G Wu, PM Sher, DL Hagan…

Index: Ellsworth, Bruce A.; Meng, Wei; Patel, Manorama; Girotra, Ravindar N.; Wu, Gang; Sher, Philip M.; Hagan, Deborah L.; Obermeier, Mary T.; Humphreys, William G.; Robertson, James G.; Wang, Aiying; Han, Songping; Waldron, Thomas L.; Morgan, Nathan N.; Whaley, Jean M.; Washburn, William N. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 17 p. 4770 - 4773

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Citation Number: 58

Abstract

Inhibition of sodium-dependent glucose transporter 2 (SGLT2), the transporter that is responsible for renal re-uptake of glucose, leads to glucosuria in animals. SGLT-mediated glucosuria provides a mechanism to shed excess plasma glucose to ameliorate diabetes- related hyperglycemia and associated complications. The current study demonstrates that the proper relationship of a 4′-substituted benzyl group to a β-1C-phenylglucoside is ...