Tetrahedron letters

Transesterification of trialkyl phosphates from alkyl bromides

C Lherbet, R Castonguay, JW Keillor

Index: Lherbet, Christian; Castonguay, Roselyne; Keillor, Jeffrey W. Tetrahedron Letters, 2005 , vol. 46, # 20 p. 3565 - 3567

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Citation Number: 4

Abstract

The treatment of trialkyl phosphate with different alkyl bromides provides facile access to mixed phosphate esters. The presence of substoichiometric amounts of lithium bromide was found to be critical to this transesterification process, supporting a mechanism involving initial generation of phosphate anion, followed by its nucleophilic attack on alkyl bromide.