1, 4-Dihydropyridine antagonist activities at the calcium channel: a quantitative structure-activity relationship approach

RA Coburn, M Wierzba, MJ Suto, AJ Solo…

Index: Coburn; Wierzba; Suto; Solo; Triggle Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2103 - 2107

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Citation Number: 140

Abstract

The effect of 46 1, 4-dihydropyridine-type calcium channel antagonists on the tonic contractile response of longitudinal muscle strips of guinea pig ileum was determined. 2, 6- Dimethyl-3, 5-dicarbomethoxy-4-phenyl-1, 4-dihydropyridine (13) and 13 ortho-, 15 meta-, and seven para-monosubstituted and 10 polysubstituted aromatic derivatives of 13 were studied. The pharmacological activities of the monosubstituted derivatives were best ...