The synthesis of 3-fluoroaspartic acid
M Hudlicky
Index: Hudlicky, M. Journal of Fluorine Chemistry, 1988 , vol. 40, p. 99 - 108
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Citation Number: 15
Abstract
Abstract A new synthesis of 3-fluoroaspartic acid is based on the reaction of dibenzyl difluoromaleate (3) with dibenzylamine. Reduction of this product (4) with sodium cyanoborohydride gave dibenzyl 2-dibenzylamino-3-fluorosuccinate (5), and thence hydrogenolysis of the benzyl groups afforded fluoroaspartic acid (6). Stereochemistry of the products and of the intermediates is discussed.
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