(1-Butyl-4-piperidinyl) methyl 8-amino-7-chloro-1, 4-benzodioxane-5-carboxylate hydrochloride: a highly potent and selective 5-HT4 receptor antagonist derived from …

…, KR Mulholland, SK Rahman, S Starr…

Index: Gaster; Jennings; Joiner; King; Mulholland; Rahman; Starr; Wyman; Wardle; Ellis; Sanger Journal of Medicinal Chemistry, 1993 , vol. 36, # 25 p. 4121 - 4123

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Citation Number: 37

Abstract

Functional serotonin 5-HT4 receptors have been identified in the central nervous system (CNS) and periphery and in several animal species including human, pig, guinea pig, rat, mouse1 and dog. z4 The first antagonist reported to act at this receptor was the 5-HT3 receptor antagonist ICs 205930 (tropisetron, 1): and this compound was subsequently used to characterize 5-HT4 receptor-mediated pharmacological responses in several ...