Chemistry Letters

Lewis Acid-Promoted Reaction of. BETA.,. BETA.-Difluorinated N, O-Acetal with Silylated Nucleophiles.

T Tsukamoto, T Kitazume

Index: Tsukamoto, Takashi; Kitazume, Tomoya Chemistry Letters, 1992 , # 7 p. 1377 - 1380

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Citation Number: 9

Abstract

Lewis acid-promoted reaction of ethyl 3-ethoxy-2, 2-difluoro-3-(dimethylamino) propionate (1) with some silylated nucleophiles afforded β, β-difluoroamines in good yields. The formation of iminium ion intermediate from 1 and BF 3· OEt 2 was confirmed by 19 F and 13 C NMR spectroscopy.