Journal of the American Chemical Society

Antispasmodics. II. Basic Esters of Some Polynuclear Carboxylic Acids1

RR Burtner, JW Cusic

Index: Burtner; Cusic Journal of the American Chemical Society, 1943 , vol. 65, p. 1582

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Citation Number: 44

Abstract

In the previous paper2 it was observed that the formation of a carbon-carbon bond or bridge between the two benzene nuclei in certain basic esters of diphenylacetic acid resulted in a marked increase in spasmolytic activity without increasing the toxicity. Thus 0- diethylaminoethyl fluorene-9-carboxylate which possessed the highest therapeutic index of the series, is approximately six times as effective as the corresponding ester of ...