Synthesis, chemical, and biological properties of vinylogous hydroxamic acids: dual inhibitors of 5-lipoxygenase and IL-1 biosynthesis

SW Wright, RR Harris, JS Kerr, AM Green…

Index: Wright, Stephen W.; Harris, Richard R.; Kerr, Janet S.; Green, Alicia M.; Pinto, Donald J.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4061 - 4068

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Citation Number: 28

Abstract

Vinylogous hydroxamic acids (3-(N-hydroxy-N-alkylamino)-2-propen-l-ones, VHA) were prepared as antiinflammatory agents. The synthesis, chemical properties, and in vitro biological activities of these relatively unexplored compounds are described. The VHAs were prepared by condensation of the appropriate N-substituted hydroxylamine with any of the three reagents: al, &dicarbonyl compound (method A); a vinylogous amide (method B); ...