Synthesis and anticonvulsant activity of enaminones. 2. Further structure-activity correlations

KR Scott, IO Edafiogho, EL Richardson…

Index: Scott, K. R.; Edafiogho, Ivan O.; Richardson, Erica L.; Farrar, Vida A.; Moore, Jacqueline A.; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 14 p. 1947 - 1955

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Citation Number: 92

Abstract

This report continues the in-depth evaluation of methyl 4-[(p-chlorophenyl) amino]-6-methyl- 2-oxocyclohex-3-en-l-oate, 1 (ADD 196022)) and methyl 4-(benzylamino)-6-methyl-2- oxocyclohex-3-en-l-oate, 2, two potent anticonvulsant enaminones. These compounds were evaluated employing the amygdala kindling model. Neither 1 nor 2 was active against amygdala kindled seizures, further supporting the corneal kindled model as a definitive ...