Apoptosis

Attenuation of NF-κB and activation of Nrf2 signaling by 1, 2, 4-triazine derivatives, protects neuron-like PC12 cells against apoptosis

…, M Amini, AD Amirabad, A Shafiee, F Khodagholi

Index: Tusi, Solaleh Khoramian; Ansari, Niloufar; Amini, Mohsen; Amirabad, Azim Dehghani; Shafiee, Abbas; Khodagholi, Fariba Apoptosis, 2010 , vol. 15, # 6 p. 738 - 751

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Citation Number: 49

Abstract

Abstract Oxidative stress has been implicated in the etiology of neurodegenerative diseases and aging. Indeed, accumulation of reactive oxygen species, such as hydrogen peroxide, generated by inflammatory cells, leads to oxidative stress, which may contribute to the neuronal degeneration observed in a wide variety of neurodegenerative disorders of the central nervous system, such as Alzheimer's disease. The present study indicates that H 2 ...