Synthesis and anti-aggregative activity of novel ω-achiral carba-analogues of prostacyclin

M Lopp, G Kobzar, M Bergmann, T Pehk, A Lopp…

Index: Lopp; Kobzar; Bergmann; Pehk; Valimae; Viigimaa; Lille European Journal of Medicinal Chemistry, 1992 , vol. 27, # 2 p. 155 - 159

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Citation Number: 3

Abstract

Abstract Novel stable bicyclo [3.3. 0] octanic and bicyclo [4.2. 0] octanic 13, 14- didehydrocarbacyclins 1a–c, 2a bearing an achiral cyclohexanoic group at C-14 were synthesized. These analogues have been characterized by 13 C NMR spectroscopy. Compounds 1a–c and 2a were tested on rabbit and human platelet-rich blood plasma and 1a–c on rat stomach and guinea pig trachea smooth muscles. E-isomers of 1a–b were ...