N-Terminal amino acid side-chain cleavage of chemically modified peptides in the gas phase: A mass spectrometry technique for N-terminus identification

A Chacon, DS Masterson, H Yin, DC Liebler…

Index: Chacon, Almary; Masterson, Douglas S.; Yin, Huiyong; Liebler, Daniel C.; Porter, Ned A. Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 18 p. 6213 - 6222

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Citation Number: 25

Abstract

Although genome databases have become the key for proteomic analyses, de novo sequencing remains essential for the study of organisms whose genomes have not been completed. In addition, post-translational modifications present a challenge in database searching. Recognition of the b or y-ion series in a peptide MS/MS spectrum as well as identification of the b1-and yn− 1-ions can facilitate de novo analyses. Therefore, it is ...