Tetrahedron letters

The tert-BUTYL sulfoxide directed ortho metalation group. New synthetic methodology for substituted aromatics and pyridines and comparisons with others metalation …

C Quesnelle, T Iihama, T Aubert, H Perrier…

Index: Quesnelle; Iihama; Aubert; Perrier; Snieckus Tetrahedron Letters, 1992 , vol. 33, # 19 p. 2625 - 2628

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Citation Number: 55

Abstract

Abstract Details of the directed ortho metalation of tert-butyl phenyl sulfoxide (1 and 2-and 4- tert-butyl pyridyl sulfoxides (3a, b are described along with comparisons with established metalation directors (CONR 2, OCONR 2, OMOM, SO 2 t-Bu) via inter-and intramolecular competition experiments.