A new synthetic route to 2-hydroxynaphthalene-1-carboxylic acid derivatives. An efficient access to the naphthalene moiety of neocarzinostatin chromophore
…, A Yamashita, K Hiroya, K Fukumoto, T Kametani
Index: Shishido; Yamashita; Hiroya; Fukumoto; Kametani Tetrahedron, 1989 , vol. 45, # 18 p. 5791 - 5804
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Citation Number: 11
Abstract
Thermolyses of the 1-carbomethoxy-1-alkenyloxybenzocyclobutenes 4a–d produced the dihydronaphthalenes 7a–d via chemoselective electrocyclic reaction of Eo- quinodimethanes in good yields. Then, 7a, b, d were easily converted to the 2-naphthol 9 (R1= R2= H) by sequential dehydrogenation and deprotection. The method of conversion developed here has been successfully applied to an efficient synthesis of the ...
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