The Journal of organic chemistry

Ugi reactions with ammonia offer rapid access to a wide range of 5-aminothiazole and oxazole derivatives

MJ Thompson, B Chen

Index: Thompson, Mark J.; Chen, Beining Journal of Organic Chemistry, 2009 , vol. 74, # 18 p. 7084 - 7093

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Citation Number: 40

Abstract

A series of Ugi reactions has been successfully performed using ammonia as the amine component, employing 2, 2, 2-trifluoroethanol as a non-nucleophilic solvent in order to suppress known side reactions. Utilizing concentrated aqueous ammonia as a convenient source, this approach offered a simple, one-step assembly of Ugi adducts suitable for elaboration into a variety of 5-aminoazole compounds through postcondensation ...