Synthesis of Novel N-(2-Hydroxyphenyl) arylsulfonamides as Selective HDAC Inhibitory and Cytotoxic Agents

J Kim, P Chun, HR Moon

Index: Kim, Jungsu; Chun, Pusoon; Moon, Hyung Ryong Bulletin of the Korean Chemical Society, 2013 , vol. 34, # 5 p. 1487 - 1493

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Citation Number: 2

Abstract

Abstract Based on the finding that the 2-aminobenzamido group of MS-275 plays a crucial role in inhibiting HDACs through chelation of zinc existing at the active site of HDAC enzymes, novel N-(2-hydroxyphenyl) arylsulfonamide derivatives were synthesized for their potential ability to inhibit HDACs and evaluated for anticancer activity against human breast cancer cell line (MCF-7). Although the synthesized arylsulfonamides have failed to ...