Caulerpenyne–colchicine hybrid: Synthesis and biological evaluation
…, L Commeiras, P Barbier, V Bourgarel-Rey…
Index: Bourdron, Julien; Commeiras, Laurent; Barbier, Pascale; Bourgarel-Rey, Veronique; Pasquier, Eddy; Vanthuyne, Nicolas; Hubaud, Jean-Claude; Peyrot, Vincent; Parrain, Jean-Luc Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 16 p. 5540 - 5548
Full Text: HTML
Citation Number: 17
Abstract
Tubulin, the major structural component of microtubules, participates actively in mitotic spindle formation and chromosomal organization during cell division. Thus, this protein is a target of anti-mitotic drugs called anti-tubulin agents. Since only a few molecules like taxoids or Vinca-alkaloids are used for cancer chemotherapy, a lot of energy is being spent in finding new anti-mitotic drugs. One of the approaches consists in the synthesis and analysis of ...
Related Articles:
Synthesis of gingerol and diarylheptanoids
[Sabitha, Gowravaram; Srinivas, Chitti; Reddy, Teega Rammohan; Yadagiri, Kurra; Yadav, Jhillu Singh Tetrahedron Asymmetry, 2011 , vol. 22, # 24 p. 2124 - 2133]
Synthesis of (S)-(−)-N-acetylcolchinol using intramolecular biaryl oxidative coupling
[Besong, Gilbert; Jarowicki, Krzysztof; Kocienski, Philip J.; Sliwinski, Eric; Boyle, F. Thomas Organic and Biomolecular Chemistry, 2006 , vol. 4, # 11 p. 2193 - 2207]
[Rosowsky, Andre; Chen, Han; Fu, Hongning; Queener, Sherry F. Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 1 p. 59 - 67]
[Kato; Kido; Wu; Yoshikoshi Bulletin of the Chemical Society of Japan, 1974 , vol. 47, # 4 p. 1516 - 1521]
Synthesis of gingerol and diarylheptanoids
[Sabitha, Gowravaram; Srinivas, Chitti; Reddy, Teega Rammohan; Yadagiri, Kurra; Yadav, Jhillu Singh Tetrahedron Asymmetry, 2011 , vol. 22, # 24 p. 2124 - 2133]