Stereoselective syntheses of 11-α-methoxycurvularin and 11-β-methoxycurvularin
GV Reddy, RSC Kumar, KS Babu, JM Rao
Index: Venkateswar Reddy; Sateesh Chandra Kumar; Suresh Babu; Madhusudana Rao Tetrahedron Letters, 2009 , vol. 50, # 28 p. 4117 - 4120
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Citation Number: 24
Abstract
A stereoselective synthesis of potent cytotoxic macrolides, 11-α-methoxycurvularin and 11-β- methoxycurvularin has been accomplished. The synthesis entailed Maruoka asymmetric allylation to introduce the stereocentres at C-11 and the key fragment was installed by using Grubbs cross-metathesis followed by CBS-reduction.
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