The reaction of glyoxylic acid with ammonia revisited

AJ Hoefnagel, H Van Bekkum…

Index: Hoefnagel, Anthonius J.; Bekkum, Herman van; Peters, Joop A. Journal of Organic Chemistry, 1992 , vol. 57, # 14 p. 3916 - 3921

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Citation Number: 24

Abstract

Upon addition of ammonia or an alkylamine to glyoxylic acid an ammonium derivative of glyoxylic acid precipitates quantitatively. With the use of solid-state 13C and 16N NMR spectroscopy, it is shown that adducts of glyoxylic acid and ammonia or the alkylamine are obtained. These compounds are not stable in aqueous solution. The compositions of the aqueous solutions have been investigated by'H, 13C, lSN, and 170 NMR. Under basic ...