Novel thiazolidine-2, 4-diones as potent euglycemic agents.

…, DA Clark, SW Goldstein, RE McDermott…

Index: Hulin, Bernard; Clark, David A.; Goldstein, Steven W.; McDermott, Ruth E.; Dambek, Paul J.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1853 - 1864

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Citation Number: 114

Abstract

A new series of thiazolidine-2, 4-diones was obtained by replacing the ether function of englitazone with various functional groups, ie, a ketone, alcohol, or olefin moiety. Theae compounds lower blood glucose levels in the genetically obese and insulin-resistant ob/ob mouse. Appending an oxazole-based group at the terminus of the chain provided highly potent compounds.