Silica sulfuric acid/NaNO2 as a novel heterogeneous system for the chemoselective N-nitrosation of secondary amines under mild conditions

MA Zolfigol, A Bamoniri

Index: Zolfigol, Mohammad Ali; Bamoniri, Abdolhamid Synlett, 2002 , # 10 p. 1621 - 1624

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Citation Number: 75

Abstract

Abstract Neat chlorosulfonic acid reacts with silica gel to give silica sulfuric acid in which sulfuric acid is immobilized on the surface of silica gel via a covalent bond. A combination of silica sulfuric acid and sodium nitrite in the presence of wet SiO 2 was used as an effective nitrosating agent for the nitrosation of secondary amines to their corresponding nitroso derivatives under mild and heterogeneous conditions in excellent yields.