New small molecule inhibitors of hepatitis C virus
…, C Cai, S Kota, V Takahashi, F Ni, AD Strosberg…
Index: Wei, Wanguo; Cai, Cuifang; Kota, Smitha; Takahashi, Virginia; Ni, Feng; Strosberg, A. Donny; Snyder, John K. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 24 p. 6926 - 6930
Full Text: HTML
Citation Number: 22
Abstract
New small molecule inhibitors of HCV were discovered by screening a small library of indoline alkaloid-type compounds. An automated assay format was employed which allowed identification of dimerization inhibitors of core, the capsid protein of the virus. These compounds were subsequently shown to block production of infectious virus in hepatoma cells.
Related Articles:
[Asgatay, Saaidia; Champion, Christine; Marloie, Gael; Drujon, Thierry; Senamaud-Beaufort, Catherine; Ceccaldi, Alexandre; Erdmann, Alexandre; Rajavelu, Arumugam; Schambel, Philippe; Jeltsch, Albert; Lequin, Olivier; Karoyan, Philippe; Arimondo, Paola B.; Guianvarc'H, Dominique Journal of Medicinal Chemistry, 2014 , vol. 57, # 2 p. 421 - 434]
Synthetic N-pyridinyl (methyl)-indol-3-ylpropanamides as new potential immunosuppressive agents
[Carbonnelle, Delphine; Lardic, Morgane; Dassonville, Alexandra; Verron, Elise; Petit, Jean-Yves; Duflos, Muriel; Lang, Francois European Journal of Medicinal Chemistry, 2007 , vol. 42, # 5 p. 686 - 693]
New N-pyridinyl (methyl)-indolalkanamides acting as topical inflammation inhibitors
[Dassonville, Alexandra; Breteche, Anne; Evano, Johan; Duflos, Muriel; Le Baut, Guillaume; Grimaud, Nicole; Petit, Jean-Yves Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 21 p. 5441 - 5444]
New N-pyridinyl (methyl)-indolalkanamides acting as topical inflammation inhibitors
[Dassonville, Alexandra; Breteche, Anne; Evano, Johan; Duflos, Muriel; Le Baut, Guillaume; Grimaud, Nicole; Petit, Jean-Yves Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 21 p. 5441 - 5444]