A practical synthesis of highly functionalized aryl nitriles through cyanation of aryl bromides employing heterogeneous Pd/C: in quest of an industrially viable process
M Hatsuda, M Seki
Index: Hatsuda, Masanori; Seki, Masahiko Tetrahedron, 2005 , vol. 61, # 41 p. 9908 - 9917
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Citation Number: 106
Abstract
Preparation of aryl nitrile through classical Rosenmund-von Braun reaction of aryl bromide resulted in a poor yield (61%) due to a high reaction temperature (165° C) and a lack of efficient procedure for separating from a large quantity of heavy metal waste (Cu salts). To address these issues, a practical synthesis of multifunctional aryl nitriles through cyanation of aryl bromides has been developed with heterogeneous Pd/C used as the catalyst. ...
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