Synthesis and preliminary evaluation of (S)-2-(4′-carboxycubyl) glycine, a new selective mGluR1 antagonist

…, G Costantino, E Giovagnoni, L Mattoli, I Brabet…

Index: Pellicciari, Roberto; Costantino, Gabriele; Giovagnoni, Emiliano; Mattoli, Luisa; Brabet, Isabelle; Pin, Jean-Philippe Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 12 p. 1569 - 1574

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Citation Number: 30

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The synthesis and the pharmacological evaluation at metabotropic glutamate receptors of S-2-(4′-carboxy-cubyl)glycine (ACUDA, 9) are described. S-2-(4′-Carboxy-cubyl)glycine is a structurally novel group I selective antagonist for mGluR1 subtype.