Unprecedented synthesis of alkynylphosphine-boranes through room-temperature oxidative alkynylation

K Jouvin, R Veillard, C Theunissen, C Alayrac…

Index: Jouvin, Kevin; Veillard, Romain; Theunissen, Cedric; Alayrac, Carole; Gaumont, Annie-Claude; Evano, Gwilherm Organic Letters, 2013 , vol. 15, # 17 p. 4592 - 4595

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Citation Number: 33

Abstract

An original and user-friendly synthesis of alkynylphosphine-boranes, useful building blocks in organic synthesis, based on an oxidative P-alkynylation reaction with readily available copper acetylides is reported. The ability of a secondary phosphine protected with a borane to undergo oxidative coupling without oxidation of the P-moiety is demonstrated for the first time. The reaction, which proceeds at room temperature, is applicable to the preparation ...