Discovery and Biological Characterization of (2 R, 4 S)-1′-Acetyl-N-{(1 R)-1-[3, 5-bis (trifluoromethyl) phenyl] ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4, 4′- …

R Di Fabio, G Alvaro, C Griffante, DA Pizzi…

Index: Sabbatini, Fabio M.; Fabio, Romano Di; Griffante, Cristiana; Pentassuglia, Giorgio; Zonzini, Laura; Melotto, Sergio; Alvaro, Giuseppe; Capelli, Anna M.; Pippo, Lara; Perdona', Elisabetta; Denis, Yves St.; Costa, Silvano; Corsi, Mauro Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 2 p. 623 - 627

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Citation Number: 18

Abstract

A large body of compelling preclinical evidence supports the clinical use of neurokinin (NK) receptor antagonists in a plethora of CNS and non-CNS therapeutic areas. The significant investment made in this area over the past 2 decades culminated with the observation that NK1 receptor antagonists elicited clinical efficacy in major depression disorders. In addition, aprepitant (Merck) was launched as a new drug able to prevent chemotherapy-induced ...