Advanced Synthesis & Catalysis

Rhodium??Catalyzed Oxidative ortho??Acylation of Aryl Ketone O??Methyl Oximes with Aryl and Alkyl Aldehydes

Y Yang, B Zhou, Y Li

Index: Yang, Yaxi; Zhou, Bing; Li, Yuanchao Advanced Synthesis and Catalysis, 2012 , vol. 354, # 16 p. 2916 - 2920

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Citation Number: 46

Abstract

Abstract The rhodium-catalyzed oxidative ortho-acylation of aryl ketone O-methyl oximes with aryl and alkyl aldehydes via C [BOND] H bond activation is described. The cross- coupling reaction exhibits high functional group tolerance and regioselectivity under relatively mild conditions and constitutes a versatile route to a diverse library of diaryl ketones, which are difficult to obtain by the classical Friedel–Crafts acylation. Moreover, ...

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