A Mild Method for Regioselective Labeling of Aromatics with Radioactive Iodine

MH Rønnest, F Nissen, PJ Pedersen…

Index: Ronnest, Mads H.; Nissen, Felix; Pedersen, Palle J.; Larsen, Thomas O.; Mier, Walter; Clausen, Mads H. European Journal of Organic Chemistry, 2013 , # 19 p. 3970 - 3973

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Abstract

Abstract A novel technique to label ortho-, meta-, and para-trimethylsilyl-substituted aryl substituents with radioactive iodide is described. The method takes advantage of the ipso- directing and activating properties of trimethylsilyl substituents on the arenes. The method was demonstrated on a griseofulvin analogue with promising anticancer properties and on lidocaine, a widely used local anesthetic drug. Treatment of a trimethylsilyl precursor with ...

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