Enzymatic oxidation of alkyl sulfides by cytochrome P-450 and hydroxyl radical.

Y Watanabe, T Numata, T Iyanagi, S Oae

Index: Watanabe, Yoshihito; Numata, Tatsuo; Iyanagi, Takashi; Oae, Shigeru Bulletin of the Chemical Society of Japan, 1981 , vol. 54, # 4 p. 1163 - 1170

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Citation Number: 79

Abstract

The oxidation of alkyl sulfides, sulfoxides, and sulfones was examined with either rabbit liver microsomes or a reconstituted system containing purified cytochrome P-450, S-dealkylation being found to take place more readily with alkyl sulfides bearing a higher acidic α- hydrogen. Similar results were obtained in the oxidation of alkyl sulfides by hydroxyl radical. Both S-dealkylation and S-oxygenation products are presumed to be formed via the cation ...