DNA-directed alkylating agents. 5. Acridinecarboxamide derivatives of (1, 2-diaminoethane) dichloroplatinum (II)

…, G Wickham, D Thorsbourne-Palmer…

Index: Lee; Palmer; Baguley; Chin; McFadyen; Wickham; Thorsbourne-Palmer; Wakelin; Denny Journal of Medicinal Chemistry, 1992 , vol. 35, # 16 p. 2983 - 2987

Full Text: HTML

Citation Number: 82

Abstract

A series of acridine-2-and-4cahxamide-linked analogues of PtenClz has been prepared and evaluated for biological activity against several tumor cell linea in vitro and in vivo. The platinum complexes were generally more cytotoxic than the correaponding ligands against wild-type P388 leukemia cells in vitro, with acridine-4-carboxamide complexes being the more effective. In contrast to cisplatin and PtenClp, the complexes were equally active in ...