Studies on non-thiazolidinedione antidiabetic agents. 3. Preparation and biological activity of the metabolites of TAK-559

H Imoto, M Matsumoto, H Odaka, J Sakamoto…

Index: Imoto, Hiroshi; Matsumoto, Mitsuharu; Odaka, Hiroyuki; Sakamoto, Junichi; Kimura, Hiroyuki; Nonaka, Masami; Kiyota, Yutaka; Momose, Yu Chemical and Pharmaceutical Bulletin, 2004 , vol. 52, # 1 p. 120 - 124

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Citation Number: 14

Abstract

Preparation and biological activity of the metabolites of the potent antihyperglycemic and antihyperlipidemic agent,(E)-4-{4-[(5-methyl-2-phenyl-1, 3-oxazol-4-yl) methoxy] benzyloxyimino}-4-phenylbutyric acid (TAK-559)(1), were investigated. Metabolites MI (2), M- II (3), M-III (4) and M-IV (5) were synthesized and their biological activities were evaluated by in vitro and in vivo experiments. Compounds 2—4 activate human peroxisome proliferator ...