Enzyme-assisted total synthesis of the optical antipodes D-myo-inositol 3, 4, 5-trisphosphate and D-myo-inositol 1, 5, 6-trisphosphate: aspects of their structure-activity …
…, O Plettenburg, R Stricker, G Reiser…
Index: Adelt, Stephan; Plettenburg, Oliver; Stricker, Rolf; Reiser, Georg; Altenbach, Hans-Josef; Vogel, Guenter Journal of Medicinal Chemistry, 1999 , vol. 42, # 7 p. 1262 - 1273
Full Text: HTML
Citation Number: 41
Abstract
Unambiguous total syntheses of both optical antipodes of the enantiomeric pair d-myo- inositol 3, 4, 5-trisphosphate (Ins (3, 4, 5) P3) and d-myo-inositol 1, 5, 6-trisphosphate (Ins (1, 5, 6) P3) are described. The ring system characteristic of myo-inositol was constructed de novo from p-benzoquinone. X-ray data for the enzymatically resolved (1 S, 2 R, 3 R, 4 S)-1, 4- diacetoxy-2, 3-dibromocyclohex-5-ene enabled the unequivocal assignment of the ...
Related Articles:
A new resolution of (1α, 2β, 3α, 4β)-2, 3-dibromocyclohex-5-en-1, 4-diol by lipase from Mucor miehei
[Sanfilippo, Claudia; Patti, Angela; Nicolosi, Giovanni Tetrahedron Asymmetry, 2000 , vol. 11, # 5 p. 1043 - 1045]
[Block, Oliver; Klein, Georg; Altenbach, Hans-Josef; Brauer, David J. Journal of Organic Chemistry, 2000 , vol. 65, # 3 p. 716 - 721]