Tetrahedron

Nickel-catalysed sequential amination of aryl-and heteroaryl di-and trichlorides

C Desmarets, R Schneider, Y Fort

Index: Desmarets, Christophe; Schneider, Raphael; Fort, Yves Tetrahedron, 2001 , vol. 57, # 36 p. 7657 - 7664

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Citation Number: 38

Abstract

Unsymmetrical 1, 3-diaminobenzenes and diaminopyridines were efficiently prepared by reaction of 3-chloroanilines and chloroaminopyridines with amines via a nickel-catalysed amination. The Ni/2, 2′-bipyridine catalyst is also effective for the sequential amination of aryl trichlorides. After a first selective monoamination of 1, 3, 5-trichlorobenzene, the obtained 3, 5-dichloroanilines were subsequently transformed into novel and ...