Potent bacterial mutagens produced by chlorination of simulated poultry chiller water

…, LA Harden, RE Wilson, M Benson…

Index: Haddon, William F.; Binder, Ronald G.; Wong, Rosalind Y.; Harden, Leslie A.; Wilson, Robert E.; Benson, Mabry; Stevens, Kenneth L. Journal of Agricultural and Food Chemistry, 1996 , vol. 44, # 1 p. 256 - 263

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Citation Number: 6

Abstract

Hypochlorite treatment of a simulated food-processing mixture produces 3, 4- dichloromaleimide and 3, 3-dichloro-4-(dichloromethylene)-2, 5-pyrrolidinedione (C5HCl4NO2). The tetrachloro compound and two analogs, which can be synthesized from citraconic anhydride and itaconic anhydride, are direct-acting Ames mutagens in Salmonella typhimurium TA100 tester strain. These novel five-carbon cyclic imides are structurally ...