Organic preparations and procedures international

An Improved Synthesis of 1-(2-Hydroxyethyl) uracil

B Garnaik

Index: Garnaik, Baijayantimala Organic Preparations and Procedures International, 1995 , vol. 27, # 6 p. 657 - 659

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Abstract

These results are particularly interesting in view of the few reported direct monoalkylation of uracil. I-Benzyluracil has been synthesized by direct monoalkylation with benzyl chloride of uracil in aqueous sodium hydroxide! The reduction of the 56-double bond of N-alkylated uracils with lithium tris-s-butylborohydride afforded the corresponding 5, Gdihydro derivatives and the method also could be used for alkylation of the 5-position of n- ...