Design and synthesis of novel stiripentol analogues as potential anticonvulsants
…, KM Amin, M Abdel-Rehim, MF El-Behairy
Index: Aboul-Enein, Mohamed N.; El-Azzouny, Aida A.; Attia, Mohamed I.; Maklad, Yousreya A.; Amin, Kamilia M.; Abdel-Rehim, Mohamed; El-Behairy, Mohammed F. European Journal of Medicinal Chemistry, 2012 , vol. 47, # 1 p. 360 - 369
Full Text: HTML
Citation Number: 41
Abstract
A series of stiripentol (STP) analogues namely, 2-[(1E)-1-(1, 3-benzodioxol-5-yl)-4, 4- dimethylpent-1-en-3-ylidene]-N-(aryl/H) hydrazinecarboxamides 7a–h,(±)-(5RS)-N-(aryl/H)- (1, 3-benzodioxol-5-yl)-3-tert-butyl-4, 5-dihydro-1H-pyrazole-1-carboxamides (±)-8a–h, and (±)-[(5RS)-(1, 3-benzodioxol-5-yl)-3-tert-butyl-4, 5-dihydro-1H-pyrazol-1-yl](aryl) methanones (±)-13a–f was synthesized by adopting appropriate synthetic routes and was ...
Related Articles:
[Qi, Baohui; Tao, Haiyan; Wu, Di; Bai, Jinying; Shi, Yandan; Gong, Ping Archiv der Pharmazie, 2013 , vol. 346, # 8 p. 596 - 609]
Design and synthesis of novel triazole antifungal derivatives by structure-based bioisosterism
[Sheng, Chunquan; Che, Xiaoying; Wang, Wenya; Wang, Shengzheng; Cao, Yongbing; Miao, Zhenyuan; Yao, Jianzhong; Zhang, Wannian European Journal of Medicinal Chemistry, 2011 , vol. 46, # 11 p. 5276 - 5282]
[Singh, Hemendra Pratap; Pandeya; Chauhan; Sharma, Chandra Shekhar Medicinal Chemistry Research, 2011 , vol. 20, # 1 p. 74 - 80]