A New Co2 (CO) 8-Mediated Tandem [5+ 1]/[2+ 2+ 1]-Cycloaddition Reaction: A One-Pot Synthesis of Tricyclic δ-Lactones from cis-Epoxy Ene-ynes

A Odedra, CJ Wu, RJ Madhushaw…

Index: Odedra, Arjan; Wu, Chang-Jung; Madhushaw, Reniguntala J.; Wang, Su-Lein; Liu, Rai-Shung Journal of the American Chemical Society, 2003 , vol. 125, # 32 p. 9610 - 9611

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Citation Number: 22

Abstract

In the presence of Co2 (CO) 8 and CO, cis-epoxyalkynes bearing a tether olefin undergo a tandem [5+ 1]/[2+ 2+ 1]-cycloaddition to give tricyclic δ-lactones efficiently in a one-pot operation. The reaction mechanism is proposed to involve a cobalt-coordinated cyclic allene species.

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