Tetrahedron Letters

New route synthesis of indolizines via 1, 3-dipolar cycloaddition of pyridiniums and alkynes

Y Shang, M Zhang, S Yu, K Ju, C Wang, X He

Index: Shang, Yongjia; Zhang, Min; Yu, Shuyan; Ju, Kai; Wang, Cuie; He, Xinwei Tetrahedron Letters, 2009 , vol. 50, # 50 p. 6981 - 6984

Full Text: HTML

Citation Number: 27

Abstract

A convenient synthesis of 2, 3-di and 1, 2, 3-trisubstituted indolizines has been achieved via a 1, 3-dipolar cycloaddition of pyridiniums and alkynes. Various alkynes and diynes were used instead of dimethyl acetylenedicarboxylate (DMAD) and its analogues in the traditional method. The corresponding 1, 2, 3-trisubstituted indolizines are useful building blocks for the construction of complex indolizine derivatives.