Selective Electrosynthesis of (Trimethylsilyldifluoro) methylbenzene, a PhCF2-Precursor; Conditions for a Molar Scale Preparation without HMPA

…, MP Léger-Lambert, C Biran, F Serein-Spirau…

Index: Clavel; Leger-Lambert; Biran; Serein-Spirau; Bordeau; Roques; Marzouk Synthesis, 1999 , # 5 p. 829 - 834

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Citation Number: 13

Abstract

Abstract: Electrochemical reductive silylation of trifluoromethylbenzene by the sacrificial anode technique selectively led, in a THF/DMPU mixture instead of THF/HMPA and according to the charge passed, to the corresponding mono-, bis-or tris-trimethylsilyl derivatives, respectively PhCF2TMS, PhCF (TMS) 2 and PhC (TMS) 3. This reaction, without any chemical equivalent, was extended to a molar scale synthesis, using a tubular flow ...

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