An Enzyme??Labile Linker Group for Organic Syntheses on Solid Supports

…, V Jungmann, H Waldmann

Index: Sauerbrei, Bernd; Jungmann, Volker; Waldmann, Herbert Angewandte Chemie - International Edition, 1998 , vol. 37, # 8 p. 1143 - 1146

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Citation Number: 75

Abstract

Abstract Lipases and esterases can be used to fragment the 4-acetyloxybenzyloxy group used as a linker for organic synthesis on solid supports.(A support-bound compound is shown on the right; the enzyme-labile bond is marked with an arrow.) This enzyme-initiated fragmentation proceeds under very mild conditions (pH 6–7, room temperature), and the compounds of interest (amines, alcohols, carboxylic acids; X= NH, O, CR 2) constructed ...