Chelation Assistance in the Activation of Csp3-S Bonds in Nickel-Catalyzed Cross-Coupling Reactions

KT Wong, TM Yuan, MC Wang, HH Tung…

Index: Wong, Ken-Tsung; Yuan, Tien-Min; Wang, Maw Cherng; Tung, Hsiao-Hsian; Luh, Tien-Yau Journal of the American Chemical Society, 1994 , vol. 116, # 20 p. 8920 - 8929

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Citation Number: 20

Abstract

Abstract: An unprecedented chelation approach to activate C, A bonds in nickel-catalyzed cross-coupling reactions is described. Our theme was based on the formation of a chelation complex which results in the enhancement of the reactivity of aliphatic carbon-sulfur bonds. When two dithioacetal functionalities are located in close proximity, selective olefination of one of these two dithioacetal groups can thus be achieved conveniently. Depending on ...