Quantitative structure-activity relationships of N2-phenylguanines as inhibitors of herpes simplex virus thymidine kinases

J Gambino, F Focher, C Hildebrand…

Index: Gambino, Joseph; Focher, Federico; Hildebrand, Catherine; Maga, Giovanni; Noonan, Timothy; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 16 p. 2979 - 2983

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Citation Number: 20

Abstract

HF 0 0.14-0.34 0 H n-ChHI1 0 2.39-0.15 0-__'Substituent parameters were obtained from ref 6. bii values for these groups were divided by 2 to give values for meta and para positions. data set has a R that is not less than or equal to 0. As a consequence, most para substituted compounds display a decrease in binding affinity for the enzyme. This equation has a correlation coefficient 15% higher than the equivalent equation with up in place of R. The ...