Ionization constants, lipophilicity and biological studies of some novel aryl-(amino or hydroxy) ethyl amino ketones with anti-inflammatory activity

…, L Hadjipetrou-Kourounakis, PN Kourounakis

Index: Hadjipavlou-Litina, D; Rekka, E; Hadjipetrou-Kourounakis, L; Kourounakis, PN European Journal of Medicinal Chemistry, 1992 , vol. 27, # 1 p. 1 - 6

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Citation Number: 12

Abstract

Abstract The synthesized 4-(2′-hydroxy-or 2′-amino-ethyl) amino-butyrophenones or butyrothienones, a novel class of basic, anti-inflammatory compounds, are of interest, since they present major differences compared to the classical (steroidal, non steroidal or immunosuppressive) anti-inflammatory agents. Ionization constants and lipophilicity, expressed as log P, from the octanol/water system, or as RM values, from reversed phase ...